Sinopsis

This clinically oriented textbook explores medical microbiology and immunology as they relate to the practice of dentistry, including sections on the microbiologic basis of caries, periodontal disease, and endodontic infection. The book begins with a thorough discussion of immunology and then systematically covers the bacteria, fungi, viruses, and parasites that affect the human body as well as their oral manifestations. Exremely detailed illustrations throughout aid the reader in comprehending the complex interactions involved in processes such as cellular immunity, bacterial and fungal infiltration, biofilm and plaque formation, and virus entry and replication. Sections on recombinant DNA technology, molecular diagnostics and genomics familiarize the reader with new technologies and emerging fields that will impact future practice. Notable discoveries in molecular biology are highlighted throughout, and research questions are featured as well to engage understanding and critical thinking. Finally, an appendix of cases in medical microbiology challenges the reader to pose diagnoses based on clinical symptoms. This book will no doubt become the definitive textbook on microbiology for dental students and dentists.

Nejat Düzgünes, PhD, is currently Professor in the Department of Biomedical Sciences at the University of the Pacific Arthur A. Dugoni School of Dentistry. He received his PhD at the State University of New York at Buffalo in 1978, after which he went to the University of California San Francisco, first as NRSA Postdoctoral Fellow and then as an assistant research biochemist and adjunct associate professor of Pharmaceutical Chemistry, where he worked on the targeted therapy of Mycobacterium avium and the fusion of enveloped viruses, including influenza virus, SIV, and HIV, with host cells. In 1990, he was appointed chair of the Department of Microbiology at the University of the Pacific, and in 1995 he was appointed Professor. He and his team investigated the delivery of various antiviral agents, including protease inhibitors, to HIV-infected cells; gene therapy of HIV; as well as the liposmal delivery of antimycobacterial agents to M avium-infected cells. More recently, his laboratory has been working on Candida species, Porphyromonas gingivalis, broadly neutralizing anti-HIV antibodies, and the gene therapy of oral cancer. Dr Düzgünes has received several grants from the National Institutes of Health and other agencies and has been the recipient of several awards, including the United Methodist University Teacher/Scholar Award of the Year in 2015 from the University of Pacific.

Índice

Part I: Immunity
Chapter 01. The Immune System
Chapter 02. Antibodies and Complement
Chapter 03. Cellular Immunity
Chapter 04. The Immune Response to Pathogens and Immunopathogenesis
Chapter 05. Vaccines

Part II: Bacteria
Chapter 06. Bacterial Structure, Metabolism, and Genetics
Chapter 07. Bacterial Pathogenesis
Chapter 08. Antibacterial Chemotherapy
Chapter 09. Sterilization, Disinfection, and Antisepsis
Chapter 10. Microbial Identification and Molecular Diagnostics
Chapter 11. Staphylococcus
Chapter 12. Streptococcus
Chapter 13. Miscellaneous Gram-Positive Bacilli
Chapter 14. Clostridium
Chapter 15. Bordetella, Legionella, and Miscellaneous Gram-Negative Bacilli
Chapter 16. Neisseria and Neisseriaceae
Chapter 17. Spirochetes
Chapter 18. Enterobacteria, Campylobacter, and Helicobacter
Chapter 19. Mycoplasma and Ureaplasma
Chapter 20. Mycobacteria
Chapter 21. Chlamydia, Rickettsia, and Related Bacteria
Chapter 22. Vibrio, Pseudomonas, and Related Bacteria
Chapter 23. Oral Microflora and Caries
Chapter 24. Periodontal and Endodontic Infections

Part III: Fungi
Chapter 25. Fungal Structure, Replication, and Pathogenesis
Chapter 26. Fungal Diseases
Chapter 27. Antifungal Chemotherapy

Part IV: Viruses
Chapter 28. Viral Structure, Replication, and Pathogenesis
Chapter 29. Antiviral Chemothreapy
Chapter 30. Naked Capsid DNA Viruses
Chapter 31. Human Immunodeficiency Virus and Other Retroviruses
Chapter 32. Hepatitis Viruses
Chapter 33. Herpesviruses
Chapter 34. Orthomyxoviruses: Influenza Virus
Chapter 35. Paramyxoviruses: Measles, Mumps, and Respiratory Syncytial Viruses
Chapter 36. Picornaviruses
Chapter 37. Arboviruses
Chapter 38. Rhabdoviruses, Poxviruses, and Coronaviruses
Chapter 39. Rubella Virus, Filoviruses, Reoviruses, and Noroviruses

Part V: Other
Chapter 40. Prions
Chapter 41. Pathogenic Parasites