Sinopsis

This totally new book is focused on answering a single broad question: What is currently happening in various research areas that will be clinically applicable to the management of temporomandibular disorders (TMDs) in the near future? Clearly, much of the information discovered about musculoskeletal disorders through the application of new research tools and innovative experimental designs can be directly or indirectly applied to the TMJ.

However, many dental clinicians are unaware of this type of information because it is presented mainly in medical publications or nonclinical scientific journals. This book bridges the gap for the clinician, applying the latest scientific research to the clinical treatment of TMDs, with focus on the anatomy, biochemistry, neurophysiology, and psychology of the common disorders. Each chapter discusses present knowledge in the particular field before explaining how it may apply to the diagnosis and treatment of TMD patients. In addition, every chapter provides an overview of new research in the field and its potential for changing future patient care. Covering such clinically relevant topics as the relation of abnormal joint function to joint pathology, the prediction of treatment responsiveness, how sleep disorders affect TMJ and facial pain, the role of comorbid conditions in pain response and management,
and the evolving field of pharmacotherapeutics, this book is sure to transform the way clinicians think about TMDs and how they approach TMD treatment.

Contents

Section I. Understanding Regional and Widespread Pain Phenomena

1 Sensory Mechanisms of Orofacial Pain 3
Ronald Dubner, Ke Ren, and Barry J. Sessle

2 Pathophysiology of Masticatory Myofascial Pain 17
Rafael Benoliel, Peter Svensson, and Eli Eliav

3 Pathophysiology of Intracapsular Inflammation and Degeneration 33
Rüdiger Emshoff

4 Comorbid Conditions: How They Affect Orofacial Pain 47
Ana Velly, Petra Schweinhardt, and James Fricton

5 How Sleep and Pain Affect Each Other 57
Guido Macaluso, Maria C. Carra, and Gilles J. Lavigne

Section II. Assessing Susceptibility to Pain Development and Chronicity

6 Genetic Determinants of Complex Orofacial Pain Conditions 69
Christian S. Stohler

7 Quantitative Sensory Testing of Pain Responsiveness 79
Peter Svensson, Eli Eliav, and Rafael Benoliel

8 Predicting Treatment Responsiveness: Somatic and Psychologic Factors 91
Richard Ohrbach and Thomas List

Section III. Biomechanics of TMJ Function

9 Biomechanics and Mechanobiology of the TMJ 101
Sandro Palla and Luigi M. Gallo

10 Finite Element Analysis of the TMJ 113
Jan Harm Koolstra

11 Lubrication of the TMJ 123
Yehuda Zadik and Dorrit W. Nitzan

Section IV. Diagnostic Technology

12 Imaging of the TMJ and Associated Structures 133
David C. Hatcher

13 Brain Imaging of Pain Phenomena 141
Geoffrey E. Gerstner, Eric Ichesco, and Tobias Schmidt-Wilcke

14 Synovial Fluid Analysis and Biomarkers of TMJ Disease 155
Regina Landesberg and Sunil Wadhwa

Section V. Therapeutic Advances

15 Developmental and Evolutionary Perspectives on TMJ Tissue Engineering 167
David A. Reed, Robert P. Scapino, Callum F. Ross, Di Chen, and Thomas G. H. Diekwisch

16 Injectable Compounds to Treat TMJ Pain and Degenerative Joint Disease 177
Songsong Zhu and Jing Hu

17 Pharmacologic Management of TMD Pain 185
Stephan A. Schug, Stefan Lauer, and Robert E. Delcanho

Appendix of Abbreviations 195
Index 197